Publications . . Patents and Applications . .Conference Presentations

 

Publications

General overviews of the field:

1. Ran, N.; Zhao, T.; Tao, J. “Recent Applications of Biocatalysis in Developing Green Chemistry for Chemical Synthesis at Industrial Scale”, Green Chem., 2008, DOI: 10.1039/b716045c.
2. Burkart, M., Tao, J. “Multimodular Synthases as Tools of the Synthetic Chemist”, “Multi Step Enzyme Catalyzed Processes”, Wiley, 2007, in press.
3. Tao, J.“Enzymatic Synthesis of Glycosylated Polyketides and Non-ribosomal Peptides”, Chimica Oggi/Chemistry Today, 2007, 25, 62-64.
4. Tao, J.; Zhao, L.; Ran, N.“Recent Advances in Developing Chemoenzymatic Processes for Active Pharmaceutical Ingredients”, Org. Process Res. Dev., 2007, 11, 259-267.
5. Tao, J., Burkart, M. “New Enzymes for Chemical Synthesis: Exploring Natural Product Biosynthesis in “Catalysis Applications”, Chimica Oggi/Chemistry Today, March/April 2007, 24, 6.
6. Tao, J.; Zhao, L. “An Integrated Approach to Developing Chemoenzymatic Processes”, chapter in “New Avenues to Efficient Chemical Synthesis ”, Springer-Verlag, 2007, pp115-129, in press.
7. Zhao, L.; Ran, N.; Tao, J. “Applications of Biocatalysis in the Development of Green Chemistry”, PharmaChem, September 2006, pp 34-36.
8. Tao, J.; Zhao, L. “An Integrated Approach to Applying Biocatalysis for Chemical Development”, Chemistry Today 2006, 24, 6.
9. John L. Tucker “Green Chemistry, a Pharmaceutical Perspective” Organic Process Research & Development, 2006, 315-319.
10. Tao, J.; Pettman, A.; Liese, A. “Biocatalytic Retrosynthesis”, chapter in “Industrial Biotransformations”, 2nd Ed., Liese, A.; Seelbach, K.; Wandrey, C., Wiley-VCH, 2006, pp 63-91.

 

 

Other publications contributed by our scientists:

1. Howard-Jones, A. R.; Kruger, R. G.; Lu, W.; Tao, J.; Leimkuhler, C.; Kahne, D. ; Walsh, C. T., “Kinetic Analysis of Teicoplanin Glycosyltransferases and Acyltransferase Reveal Ordered Tailoring of Aglycone Scaffold to Reconstitute Mature Teicoplanin”, J. Am. Chem. Soc., 2007, 129, 10082-10083.
2. Saenz, J.; Mitchell, M.; Bahmanyar, S.; Stankovic, N.; Perry, M.; Craig-Woods, B.; Kline, B.; Yu, S.; Albizati, K. Process Development and Scale-up of AG035029. Org. Proc. Res. Dev. 2007, 11, 30-38.
3. Xu, L., Chong, Y-H, Hwang I., D’Onofrio, A. et al. (2007). Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. Journal of Biological Chemistry, 282, 13033-13046
4. Xu, L., Benson, S.D. & Burnett, R.M. (2007). Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon, Journal of Structural Biology, 157, 424-431.
5. 5. Ran, N.; Frost, J. W. “Directed Evolution of 2-Keto-3-deoxy-6-phosphogalactonate Aldolase to Replace 3-Deoxy-D-arabino-heptulosonate 7-Phosphate Synthase”, J. Am. Chem. Soc. 2007, 129, 6130-6139.
6. Ran, N.; Draths, K. M.; Frost, J. W. “Creation of a Shikimate Pathway Variant”, J. Am. Chem. Soc. 2004, 126, 6856-6857.
7. Ran, N.; Knop, D. R.; Draths, K. M.; Frost, J. W. “Benzene-Free Synthesis of Hydroquinone”, J. Am. Chem. Soc. 2001, 123, 10927-10934.
8. Xie, J.; Feng, J.; Garcia, E.; Bernett, M.; Yazbeck, D.; Tao, J. “Cloning and Optimization of a Nitrilase for the Synthesis of (3S)-3-Cyano-5-methyl Hexanoic Acid ”, J. Mol. Cat. B, 2006, 41, 75-80.
9. Camp, D.; Matthews, C.F.; Neville, S.N.; Rouns, M.; Scott, R.W.; Truong, Y. "Development of a Synthetic Process towards a Hepatitis C Polymerase Inhibitor." Org. Process Res. Dev. 2006, 10, 814-821.
10. Tucker, J.L.; Castaldi, M.J.; Chiu, C. K.F.; Couturier, M.; Gestmann, D.; “A Scaleable Process to 4-(2-hydroxy-2-methyl)-ethyl-benzylamine”, Synth. Commun. 2006, 36, 2145-2150.
11. Hu, S.; Martinez, C.; Kline,B.; Yazbeck, D.; Tao, J. “Efficient and Scalable Enzymatic Process for the Production of (2S)-4,4-Difluoro-3,3-dimethyl-N-Boc-proline, a Key Intermediate in the Synthesis of HIV Protease Inhibitors”, Org. Process. Res. Dev., 2006, 10, 650-654.
12. Yazbeck, D.; Derrick, A.; Panesar, M.; Deese, A.; Gujral, A.; Tao, J. “Enzymatic Hydrolysis of Racemic and Cis/Trans Ethyl Bicyclo[3.2.0]hept-6-ylidene-acetate and the Solvent Effects”, Org. Process. Res. Dev., 2006, 10, 655-660.
13. Yazbeck, D.; Durao, P. J.; Xie, Z.; Tao, J. “A High Throughput Metal Ion Based Methods for Nitrilase Screening”, J. Mol. Cat. B, 2006, 39, 156-159 (special issue, invited).
14. Hu, S.; Kelly, S.; Lee, S.; Tao, J.; Flahive, E. "Efficient Chemoenzymatic Synthesis of Pelitrexol via Enzymatic Differentiation of a Remote Stereocenter", Org. Lett., 2006, 8, 1653-1655. 
15. Damon, D.B.; Dugger, R.W.; Hubbs, S.E.; Scott, J.M.; Scott, R.W. “Asymmetric Synthesis of the Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib,” Org. Process Res. Dev. 2006, 10, 472-480.
16. Scott, R.W.; Neville, S.N.; Urbina, A.; Camp, D.; Stankovic, N. “Development of a Scalable Synthesis to VEGFR Inhibitor AG-28262,” Org. Process Res. Dev. 2006, 10, 296-303.
17. Gray, K. A.; Zhao, L.; Emptage, M. “Bioethanol”, Curr. Opin. Chem. Biol 2006, 10, 141-146.
18. DeMartino, J.K.; Hwang, I.; Xu, L.; Wilson, I.A.; Boger, D.L., “Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase”, J. Med. Chem. 2006, 49, 2998-3002.
19. Xu, L.; Benson, S.D.; Burnett, R.M., “Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon”, J. Struct. Biol. 2006, in press.
20. Pacholec, M.; Tao, J.; Walsh, C. T., “CouO and NovO: C-Methyltransferases for Decoration of the Aminocoumarin Scaffold in Novobiocin and Coumermycin Antibiotic Biosynthesis”, Biochemistry, 2005, 44, 14969-14976.
21. Hu, S.; Tat, D.; Martinez, C.; Yazbeck, D.; Tao, J. “An Efficient and Practical Chemoenzymatic Method for Preparing Optically Active Secondary Amines”, Org. Lett., 2005, 7, 4329-4331.
22. Liao, J.; Tao, J.; Lin, G.; Liu, D. “The Chemistry and Biology of Sphingolipids”, Tetrahedron 2005, 61, 4715-4733 (review, invited).
23. Tao, J.; Hu, S.; Tian, Q.; Nayyar, N.; Srin, B. “ A Chemoenzymatic Synthesis of Ketomethylene Tripeptide Isostere”, Tetrahedron Asym. 2005, 16, 699-703.
24. Kruger, R. G.; Lu, W.; Oberthur, M.; Tao, J.; Kahne, D.; Walsh, C. T., “Tailoring of Glycopeptide Scaffolds by the Acyltransferases from the Teicoplanin and A-40,926 Biosynthesis Operons’, Chem. & Bio., 2005, 12, 131-140.
25. Bahmanyar, S.; Borer, B. C.; Kim, Y. M.; Kurtz, D. M.; Yu, S. “Proximity Effects in the Palladium-Catalyzed Substitution of Aryl Fluorides” Organic Letters 2005, 1011-1014.
26. Li, B.; Andresen, B.; Brown, M.F.; Buzon, R.A.; Chiu, C.K.F.; Couturier, M.; Dias, E.; Urban, F.J.; Jasys, V.J.; Kath, J.C.; Kissel, W.; Le, T.; Li, Z.J.; Negri, J.; Poss, C.S.; Tucker, J.L.; Whritenour, D.; Zandi, K.; “Process Development of CP-481715, a Novel CCR1 Antagonist”,  Org. Process Res. Dev. 2005, 466-471.
27. Szu, P.-h.; He, X.; Zhao, L.; Liu, H.-w. “Biosynthesis of TDP-D-desosamine: identification of a strategy for C4 deoxygenation”, Angew. Chem. Int. Ed. 2005, 44, 6742-6746.
28. Lu, W., Leimkuhler, C., Oberthür, M., Tao, J., Kahne, D., Walsh, C. T. “Characterization of a Regiospecific Epivancosaminyl Transferase GtfA and Enzymatic Reconstitution of the Antibiotic Chloroeremomycin”, Proc. Natl. Acad. Sci. U.S.A., 2004, 101, 4390-4395.
29. Sieber, S. A.; Tao, J.; Walsh, C. T.; Marahiel, M. A. “Peptidyl Thiophenols as Substrates for Nonribosomal Peptide Cyclases”, Angew. Chem. Int. Ed. Engl., 2004, 43, 493-498.
30. Martinez, C. A.; Yazbeck, Y.; Tao, J. “An Efficient Enzymatic Preparation of Rhinovirus Protease Inhibitor Intermediates”, Tetrahedron, 2004, 60, 759-764 (special issue, invited).
31. Tao, J.; McGee, K. “Development of An Efficient Synthesis of Chiral 2-Hydroxy Acids”, chapter in “Asymmetric Synthesis on Industrial Scale: Challenges, Approaches and solutions”, Schmidt, E.; Blaser, H.-U Eds., Wiley-VCH, 2004.
32. Notz, W.; Watanabe, S.; Chowdari, N. S.; Zhong, G.; Betancort, J. M.; Tanaka, F.; Barbas III, C. F. “The Scope of the Direct Proline-Catalyzed Asymmetric Addition of Ketones to Imines” Adv. Synth. Catal. 2004, 346, 1131-1140.
33. Notz, W.; Tanaka, F.; Barbas III, C. F. “Enamine-Based Organocatalysis with Proline and Diamines: The development of Direct Catalytic Asymmetric Aldol, Mannich, Michael, and Diels-Alder Reactions” Acc. Chem. Res. 2004, 37, 580-591.
34. Scott, R.W.; Fox, Darrell E.; Wong, J.W.; Burns, M.P. “Alternate Synthesis of a b-3 Adrenergic Receptor Agonist,” Org. Process Res. Dev. 2004, 8, 587-592.
35. Alsante, K.M.; Boutros, P.; Couturier, M.; Friedmann, R.C. ; Harwood, J.W. ; Horan, G. J. ; Jensen, A. J. ; Liu, Q.; Lohr, L.L. ; Morris, R.; Raggon, J.W. ; Reid, G.L. ; Santafianos, D.P. ; Sharp, T.R. ; Tucker, J.L.; Wilcox, G.E., “Pharmaceutical impurity identification: A case study using a multidisciplinary approach.”, J. Pharm. Sci. 2004, 93, 2296.
36. Andresen, B.M.; Couturier, M., Cronin, B.; D’Occhio, M.; Ewing, M.; Guinn, M.; Hawkins, J.M.; Jasys, J.V.; LaGreca, S.; Lyssikatos, J.P.; Moraski, G.; Ng, K.; Raggon, J.W.; Stewart, M.A.; Tickner, D.L.; Tucker, J.L.; Urban, F.J.; Vazquez, E.; Wei, L.; “Streamlined Process for the Synthesis of a Farnesyl Transferase inhibitor Drug Candidate”, Org. Process Res. Dev. 2004, 8, 643.
37. Zhao, L.; Han, B.; Huang, Z.; Miller, M.; Huang, H.; Malashock, D. S.; Zhu, Z.; Milan, A.; Robertson, D. E.; Weiner, D. P.; Burk, M. J. “Epoxide hydrolase-catalyzed enantioselective synthesis of chiral 1,2-diols via desymmetrization of meso-epoxides”, J. Am. Chem. Soc. 2004, 126, 11156-11157.
38. Borisova, S.A.; Zhao, L.; Melancon, C. E.; Kao, C.; Liu, H.-w. “Characterization of the glycosyltransferase activity of DesVII: analysis of and implications for the biosynthesis of macrolide antibiotics”, J. Am. Chem. Soc. 2004, 126, 6534-6535.
39. Xu, L.; Li, C.; Olson, A.J.; Wilson, I.A., “Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening”, J. Biol. Chem. 2004, 279, 50555-50565.
40. Yazbeck, D.; Martinez, C. A.; Hu, S.; Tao, J., “Challenges in the Development of an Efficient Enzymatic Process for the Pharmaceutical Industry”, Tetrahedron Asym. 2004, 15, 2757-2763 (review, invited).
41. Li, C.; Xu, L.; Wolan, D.W.; Wilson, I.A.; Olson, A.J., “Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors”, J. Med. Chem. 2004, 47, 6681-6690.
42. Yazbeck, D.; Martinez, C. A.; Hu, S.; Tao, J., “Challenges in the Development of an Efficient Enzymatic Process for the Pharmaceutical Industry”, Tetrahedron Asym. 2004, 15, 2757-2763 (review, invited).
43. Dragovich, P. S.; Tao, J. et al “Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 8. Pharmacological Optimization of Orally Bioavailable 2-Pyridone-Containing Peptidomimetics”, J. Med. Chem., 2003, 46, 4572-4585.
44. Patel, H.; Tao, J.; Walsh, C. T. “Epimerization of L-Cysteinyl to D-Cysteinyl Residue during Thiazoline Ring Formation in Siderophore Chain Elongation by Pyochelin Synthetase from Pseudomonas aeruginosa”, Biochemistry, 2003, 42, 10514-10527.
45. Kohli, R.; Burke, M.; Tao, J.; Walsh, C. T. “Chemoenzymatic Route to Macrocyclic Hybrid Peptide/polyketide-like Molecules”, J. Am. Chem. Soc. 2003, 125, 7160-7161.
46. Tao, J.; Hu, S.; Pacholec, M.; Walsh, C. T., “Synthesis of Proposed Oxidation-Cyclization-Methylation Intermediates of the Coumarin Antibiotic Biosynthetic Pathway”, Org. Lett., 2003, 5, 3233-3236.
47. Couturier, M.;Tucker, J.L.; Andresen, B.M.; DeVries, K.M.; Vanderplas, B.C.;Ito, F. “Efficient synthesis of the ?-opiod receptor agonist CJ-15161: four stereospecific inversions at a single aziridinium stereogenic center”, Tetrahedron Asymm. 2003, 14, 3517.
48. Tucker, J.L.; Couturier, M.; Leeman, K.R.; Hinderaker, M.P.; Andresen, B.M.; “Chemoselective Removal of Dimeric 1,3-Diol Impurities Generated from Methyl Grignard Addition onto Esters”, Org. Process Res. Dev. 2003, 7, 929.
49. Beaudin, J.; Bourassa, D.E.; Bowles, P.; Castaldi, M.J.; Clay, R.; Couturier, M.A.; Karrick, G.; Makowski, T.W.; McDermott, R.E.; Meltz, C.N.; Stewart, M.; Phillips, J.; Ragan, J.A.; Ripen, D.H.B.; Singer, R.A.; Tucker, J.L.; Wei, L.; “Synthesis and Purification of 6-Ethoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic Acid Benzylamide”, Org. Process Res. Dev. 2003, 7, 873.
50. Tucker, J.L.; DeVries, K.M.; Hammen, P.D.; Rose, P.R.; Raymer, B.K.; Rescek, D.; “Isolation and Identification of an Unusual Impurity in an Intermediate of RimadylÒ (Carprofen)”, Heterocycles 2003, 60, 1681.
51. Notz, W.; Tanaka, F.; Watanabe, S.; Chowdari, N. S.; Turner, J. M.; Thayumanavan, R.; Barbas III, C. F. “The Direct Organocatalytic Asymmetric Mannich Reaction: Unmodified Aldehydes as Nucleophiles.” J. Org. Chem. 2003, 68, 9624-9634.
52. Heathcock, C.H.; McLaughlin, M.; Medina, J.; Hubbs, J.L.; Wallace, G.A.; Scott, R.; Claffey, M.M.; Hayes, C.J.; Ott, G.L. “Multigram Synthesis of the C29-C51 Subunit and Completion of the Total Synthesis of Altohyrtin C (Spongistatin 2)” J. Am. Chem. Soc. 2003, 125, 12844-12849.
53. Zhao, L.; Beyer, N.J.; Borisova, S.A.; Liu, H.-w. “B-Glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae”, Biochemistry 2003, 42, 14794-14804.
54. Yazbeck, D.; Tao, J.; Martinez, C.; Kline, B.; Hu, S. “Automated Enzyme Screening Methods for the Preparation of Enantiopure Pharmaceutical Intermediates”, Adv. Syn. Cat., 2003, 345, 524-532 (special issue, invited).
55. Xu, L.; Benson, S.D.; Butcher, S.J.; Bamford, D.H.; Burnett, R.M., “The receptor binding protein P2 of PRD1, a virus targeting antibiotic-resistant bacteria, has a novel fold suggesting multiple functions”, Structure 2003, 11, 309-322.
56. Tao, J.; McGee, K. “Development of a Continuous Enzymatic Process for the Preparation of (R)-3-(4-Fluorophenyl)-2-hydroxypropionic Acid”, Org. Process. Res. Dev., 2002, 6, 520-524 (special issue, invited).
57. Cordova, A.; Notz, W.; Zhong, G.; Betancort, J. M.; Barbas III, C. F. “A Highly Enantioselective Amino Acid-Catalyzed Route to Functionalized a-Amino Acids” J. Am. Chem. Soc. 2002, 124, 1842-1843.
58. Cordova, A.; Watanabe, S.; Tanaka, F.; Notz, W.; Barbas III, C. F. “A Highly Enantioselective Route to Either Enantiomer of Both a- and b-Amino Acid Derivatives” J. Am. Chem. Soc. 2002, 124, 1866-1867.
59. Couturier, M.; Tucker, J.L.; Proulx, C.; Boucher, G.; Dube, P.; Andresen, B.M.; Ghosh, A.; “5,5-Dimethyl-[1,4,2]-dioxazoles as Versatile Aprotic Hydroxamic Acid Protecting Groups”, JOC 2002, 67, 4833.
60. Couturier, M.; Andresen, B.M.; Jorgensen, J.B.; Tucker, J.L.; Busch, F.R.; Dube, P.; am Ende, D.J.; Negri, J.T.; “Practical Large-Scale Synthesis of 3,4-Isopropylidenedioxypyrrolidine Hydrotosylate: Atom Economical Self-Hydrogenolysis of a Crystalline Borane-Benzylamine Adduct.” Org. Process Res. Dev. 2002, 42.
61. Cordova, A.; Notz, W.; Barbas III, C.F. “Direct organocatalytic aldol reactions in buffered aqueous media.” Chem. Commun. 2002, 3024-3025.
62. Cordova, A.; Notz, W.; Barbas III, C. F. “ Proline-Catalyzed One-Step Asymmetric Synthesis of 5-Hydroxy-(2E)-hexenal from Acetaldehyde.” J. Org. Chem. 2002, 67, 301-303.
63. Chen, H.; Yamase, H.; Murakami, K.; Chang, C.; Zhao, L.; Zhao, Z.; Liu, H.-w. “Expression, Purification and Characterization of Two N,N-dimethyltransferases, TylM1 and DesVI, Involved in the Biosynthesis of Mycaminose and Desosamine”, Biochemistry 2002, 41, 9163-9183.
64. Tao, J.; Guo, M. “Application of Biocatalysis in the Pharmaceutical Industry", Chapter in "Front. Biotechnol. Pharm.”, K. Zhao, Ed., Science Press, 2001.
65. Tian, Q.; Nayyar, N. K.; Babu, S.; Chen, L.; Tao, J.; Lee, S.; Tibbetts, A.; Moran, T.; Liou, J.; Guo, M.; Kennedy, T. P. “An Efficient Synthesis of a Key Intermediate for the Preparation of the Rhinovirus Protease Inhibitor AG7088 via Asymmetric Dianionic Cyanomethylation of N-Boc-l-(+)-glutamic Acid Dimethyl Ester”, Tetrahedron Lett., 2001, 42, 6807.
66. Guo, M.; Tian, Q.; Tao, J. “Recent Advances in Organic Chemistry Related to Process Research and Development", chapter in "Front. Biotechnol. Pharm.”, K. Zhao, Ed., Science Press, 2001.
67. Albizati, K. F.; Babu, S.; Birchler, A.; Busse, J. K.; Fugett, M.; Grubbs, A.; Haddach, A.; Pagan, M.; Potts, B.; Remarchuk, T.; Rieger, D.; Rodriguez, R.; Shanley, J.; Szendroi, R.; Tibbetts, T.; Whitten, K.; Borer, B. C. “A Synthesis of the HIV-Protease Inhibitor Nelfinavir from D-Tartaric Acid” Tetrahedron Lett. 2001, 6481-6485.
68. Notz, W.; Sakthivel, K.; Bui, T.; Zhong, G.; Barbas III, C. F. “Amine-Catalyzed Direct Asymmetric Mannich-type Reactions” Tetrahedron Lett. 2001, 42, 199-201.
69. Sakthivel, K.; Notz, W.; Bui, T.; Barbas III, C. F. “Amino Acid Catalyzed Direct Asymmetric Aldol Reactions: A Bioorganic Approach to Catalytic Asymmetric Carbon-Carbon Bond-Forming Reactions” J. Am. Chem. Soc. 2001, 123, 5260-5267.
70. Waldscheck, B.; Streiff, M.; Notz, W.; Kinzy, W.; Schmidt, R. R. “a(1-3)-Galactosyltransferase Inhibition Based on a New Type of Disubstrate Analogue” Angew. Chem. Int. Ed. 2001, 40, 4007-4011.
71. Couturier, M.; Andresen, B.M.; Tucker, J.L.; Dube, P.; Brenek, S.J.; Negri, J.T.; “The Use of Borane-Amine Adducts as Versatile Palladium Catalyzed Hydrogen Transfer Reagents in Methanol”, Tetrahedron Lett. 2001, 42, 2763.
72. Couturier, M.; Tucker, J.L.; Andresen, B.M.; Dube, P.; Brenek, S.J.; Negri, J.T.; “Palladium Catalyzed Activation of Borane-Amine Adducts: Rate Enhancement of Amine-Borane Methanolysis in the Reduction of Nitrobenzenes to Anilines.” Tetrahedron Lett. 2001, 42, 2285.
73. Couturier, M.; Tucker, J.L.; Andresen, B.M.; Dube, P.; Negri, J.T.; “Palladium and Raney Nickel Catalyzed Methanolic Cleavage of Stable Borane-Amine Complexes.” Org. Lett. 2001, 3, 465.
74. Notz, W.; Hartel, C.; Waldscheck, B.; Schmidt, R. R. “De Novo Synthesis of a Methylene-Bridged Neu5Ac- -(2,3)-Gal C-Disaccharide.” J. Org. Chem. 2001, 66, 4250-4260.
75. Zhao, L.; Borisova, S. A.;Yeung, S.-M.; Liu, H.-w. “Study of C-4 Deoxygenation in the Biosynthesis of Desosamine: Evidence Implicating a Novel Mechanism”, J. Am. Chem. Soc. 2001, 123, 7909-7910.
76. Zook, S. E.; Busse, J. K.; Borer, B. C. “A Concise Synthesis of the HIV-Protease Inhibitor Nefinavir via an Unusual Tetrahydrofuran Rearrangement” Tetrahedron Lett. 2000, 41, 7017-7021.
77. Notz, W.; List, B. “Catalytic Asymmetric Synthesis of anti-1,2-Diols” J. Am. Chem. Soc. 2000, 122, 7386-7387.
78. Yamase, H.; Zhao, L.; Liu, H.-w. “Engineering a hybrid sugar biosynthetic pathway: Production of L-rhamnose and its implication on dihydrostreptose biosynthesis”, J. Am. Chem. Soc. 2000, 122, 12397-12398.
79. Chang, C.; Zhao, L.; Yamase, H.; Liu, H.-w. “DesVI: A new member of the sugar N,N-dimethyltransferase family involved in the biosynthesis of desosamine”, Angew. Chem. Int. Ed. 2000, 39, 2160-2163.
80. Yu, W.H., Zhao, K.W., Ryazantsev, S., Rozengurt, N., Neufeld, E.F. “Short Term Enzyme Replacement in the Murine Model of Sanfilippo Syndrome Type B”, Mol. Genet. Metab. 2000, 71, 573-580.
81. Tu, G.H., Kirchmaier, A.L., Liggitt, D., Liu, Y., Liu, S., Yu, W.H., Heath, T.D., and Debs, R.J. “Non-replicating Epstein-Barr virus-based plasmids extend gene expression and can improve gene therapy in vivo”, J. Biol. Chem. 2000, 275, 30408-30416.
82. Xu, L.; Butcher, S.J.; Benson, S.D.; Bamford, D.H.; Burnett, R.M. “Crystallization and preliminary X-ray analysis of receptor-binding protein P2 of bacteriophage PRD1”, J. Struct. Biol. 2000, 131, 159-163.
83. Yu, W.H., Kashani-Sabet, M., Liggitt, D., Moore, D., Heath, T.D. and Debs, R.J. “Topical Gene Delivery to Murine Skin”, J Invest Dermatol. 1999, 112, 370-375.
84. Li, H.H., Yu, W.H., Rozengurt, N., Zhao, H.Z., Lyons, K.M., Anagnostaras, S. G., Fanselow, M.S., Suzuki, K, Vanier, M.T. and Neufeld, E.F. “Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase”, Proc. Nat. Acad. Sci..U.S.A., 1999, 96, 14505-14510.