Publications .
. Patents and Applications . .Conference Presentations
Patents and Applications (co-invented
by our scientists):
| 1. |
Hu,
S.; Tao, J.; Xie, J. “Process for Producing Atorvastatin,
Pharmaceutically Acceptable Salts Thereof and Intermediates Thereof”,
WO 2006134482. |
| 2. |
Liu, J.; Nayyar, N.;
Guo, M.; Wu, Z.; Borer, B. C.; Srirangam, A. N.; Mitchell, M.
B.; Li, Y.; Chu, J. “Polymorphic and amorphous forms
of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
as poly(ADP-ribose) polymerase inhibitor,” WO 2006033007. |
| 3. |
Hu, S.; Martinez, C.
A.; Tao, J.; Yazbeck, D. “An Efficient Microbial Preparation
of Capravirine Metabolites M4 and M5”, US 20050043363. |
| 4. |
Kung, P.-P.; Martinez,
C.; Tao, J. “Enantioselective Biotransformations for Preparation
of Protein Tyrosine Kinase Inhibitor Intermediates”, WO
2006021885. |
| 5. |
Hu, S.; Tat, D.; Martinez,
C. A.; Yazbeck, D.; Tao, J. “Methods for the Preparation
of Stereoisomerically Enriched Amines”, WO 2005054186. |
| 6. |
Hu, S.; Martinez, C.
A; Tao, J. “An Efficient Method for the Production of Enantiopure
Pregabalin”, US 2005283023. |
| 7. |
Kucera, D.J.; Scott,
R.W. “Compounds and process for the preparation of HIV
protease inhibitors” US20040171842, 20040204591; US20050124673;
WO 2005054187. |
| 8. |
Notz, W. R. L.; Martinez,
C. A “Convergent asymmetric synthesis route to produce
a key intermediate towards the synthesis of a glycinamide ribonucleotide
formyl transferase (GARFT) inhibitor.” WO 2004113328. |
| 9. |
Dovalsantos, E. Z.; Flahive,
E. J.; Halden, B. J.; Mitchell, M. B.; Notz, W. R. L.; Tian.
Q. O’Neill-Slawecki, “Convergent synthesis of a glycinamide
ribonucleotide formyltransferase (GARFT) inhibitor containing
a methyl substituted thiophene core and a tetrahydropyrido[2,3-d]pyrimidine
ring system and intermediates therefor.” WO 2004113337. |
| 10. |
Devries, K.M.; Caron,
S.; Hammen, P.D.; Taber, G.P.; Tucker, J.L.; Rose, P.R.; Post,
R.J.; Raymer, B.K. “Preparation of chiral carboxyphenylchromanols
via saponification of the corresponding isopropyl esters”,
US 2003158428. |
| 11. |
Barbas III, C. F.; Cordova,
A.; Notz, W. “Enantioselective methods for preparing a-
and b-amino acid derivatives.” WO 200359915 . |
| 12. |
DeVries, K.M.; Tucker
J.L.; Couturier, M.; Andresen, B.M.; “Preparation of hydroxypyrrolidinyl
ethylamine compounds useful as selective ?-opiod receptor agonists”,
US 2002161241. |
| 13. |
Tian, Q.; Nayyar, N.;
Babu, S.; Tao, J.; Moran, T.; Dagnino, R.; Remarchuk, T.; Melnick,
M.; Mitchell, L.; Bender, S. “Efficient Synthetic Routes
for the Preparation of Rhinovirus Protease Inhibitors and Key
Intermediates”, US 2002133020. |
| 14. |
Damon, D.B.; Dugger,
R.W.; Scott R.W. “Methods for Preparing 4-amino-1,2,3,4-tetrahydroquinoline-2-carboxylates,” WO
2002088069; WO 2002088085. |
| 15. |
Tucker J.L.; Hammen,
P.D.; Negri, J.T.; Mahon, K.P.; Lehner, R.S.; Wei, L.; Sklavounos,
C.; “Process for preparing 4”-substituted-9-deoxo-9a-aza-9a-homoerythromycin
A derivatives via epoxide ring cleavage/alkylamination for treating
bacterial and protozoa infections”, EP 1253153. |
| 16. |
Tucker J.L.; Colberg,
J.; “Process and Ester Derivatives for Preparation of Cephalosporins”,
WO 2002046199. |
| 17. |
DeVries, Keith M.; Tucker,
John L.; Hammen, Philip D.; Raymer, Brian K.; Rose, Peter R.;
Caron, Stephane; Taber, Geraldine P.; Post, Ronald J.; “Processes
for Preparing Chromanylbenzoic Acids”, WO 2002060888. |
| 18. |
Tao, J.; Babu, S.; Dagnino,
R.; Tian, R.; Remarchuk, T.; McGee, K.; Nayyar, N.; Moran, T. “Process
for Preparation of Amidopentenoate Peptide Analog Rhinovirus
Protease Inhibitors “, WO 2001014576. |
| 19. |
Damon, D.B.; Dugger,
R.W.; Scott, R.W. “Methods for preparing CETP inhibitors” and
intermediates US 6600045; US 6689897; US 6706881. |
| 20. |
Tian, Q.; Nayyar, N.;
Babu, S.; Tao, J.; Moran, T.; Dagnino, R.; Remarchuk, T.; Melnick,
M.; Mitchell, L.; Bender, S. “Synthetic Routes for the
Preparation of Rhinovirus Protease Inhibitors and Key Intermediates”,
WO 2001014329 |
| 21. |
Busse, J. K.; Zook, S.
E.; Borer, B. C. “Process for Preparing Oxazolines
from Tetrahydrofurans,” WO 2001029013. |
| 22. |
DeNinno, M.P.; Masamune,
H.; Scott, R.W. “Preparation of Nucleosides as Adenosine
Receptors, Antidiabetics, Enzyme Inhibitors, and for the Treatment
of Ischemia,” WO 2001023399. |
| 23. |
Scott, R.W. “Compound
and process for producing b-Andrenergic Receptor Agonists” US
6297382; US 6441181. |
| 24. |
Scott, R.W. “Process
for the Synthesis of Nucleoside Analogs” US 6271370. |
| 25. |
Hammen, P.D.; Rose, P.R.;
Tucker, J.L.; DeVries, K.M.; Rescek, D.M.; “Purification
of Carbazolemalonate Precursors of Carprofen”, US 6013808. |
| 26. |
Hammen, P.D.; Rose, P.R.;
Rescek, D.M.; Tucker, J.L.; DeVries, K.M.; “Purification
of (6-Chloro-2-Carbazolyl) Methylmalonate Dialkyl Esters Using
Acetic Acid.”, EP-965586. |
| 27. |
Babu, S.; Borer, B. C.;
Remarchuk, T. P.; Szendroi, R. J.; Whitten, K. R.; Busse, J.;
Albizati, K. F. “Methods of Making Intermediates
for the Prepn. of the HIV-Protease Inhibitor Nelfinavir,” US
5925759. |
| 28. |
Babu, S.; Borer, B. C.;
Remarchuk, T. R.; Szendroi, R. J.; Whitten, K. R.; Busse, J.
K.; Albizati, K. F. “Preparation of Intermediates
for the HIV-Protease Inhibitor Nelfinavir,” US 5705647. |
| 29. |
Zhao,
L.; Mathur, E. J.; Weiner, D.; Richardson, T.; Milan, A.; Burk,
M. J.; Han, B.; Short, J. M. “Epoxide hydrolases, nucleic
acids encoding them and methods for making and using them”,
US 6943001; 6979733. |
| 30. |
Sherman,
D. H.; Liu, H-w.; Xue, Y.; Zhao, L. “DNA Encoding Methymycin
and Pikromycin”, US 6265202 |
| 31. |
Abraham,
T. W.; Cameron, D. C.; Hicks, P. M.; McFarlan, S. C.; Millis,
J. R.; Rosazza, J.; Zhao, L.; Weiner, D. P. “Polypeptides
and biosynthetic pathways for the production of monatin and its
precursors ”, US 20050244937. |
| 32. |
Abraham,
T. W.; Cameron, D. C.; Goulson, M. J.; Hicks, P. M.; Lindley,
M. G.; McFarlan, S. C.; Millis, J. R.; Rosazza, J.; Zhao, L.;
Weiner, D. P. “Monatin tabletop sweetener compositions and
methods of making same ”, US 20050112260. |
| 33. |
Weiner,
D. P.; Hitchman, T.; Zhao, L.; Burk, M. J.; Desantis, G.; Hanson,
S.; Milan, A.; Richardson, T.; Kretz, P.; Greenberg, W. “Methods
for the Manufacture of pure single enantiomer compounds and for
selecting enantioselective enzymes”, US 20030092033. |
| 34. |
Sherman,
D. H.; Liu, H-w.; Zhao, L. “Method to Alter Sugar Moieties”,
US 20040160839. |
| 35. |
Zhao,
L.; Weiner, D. P.; Hickle, L. “Fumonisin detoxification enzyme
gene isolated from environmental microorganisms, compositions
and methods for making fumonisin-resistant transgenic plants,
and detoxification for grains and foods and feeds.” WO 2004085624. |
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